⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609350 | 0.79 | — | — | |
| SCHEMBL2534570 | 0.72 | — | — | |
| Ammonia Solution, Strong SCHEMBL28914391 | 0.72 | — | — | |
| SCHEMBL29061272 | 0.70 | — | — | |
| SCHEMBL19755650 | 0.69 | ALDH1A1 (0.62) | — | |
| SCHEMBL28611936 | 0.69 | — | — | |
| SCHEMBL15932248 | 0.67 | MEN1 (0.54) | — | |
| SCHEMBL9733403 | 0.67 | — | — | |
| SCHEMBL18675284 | 0.67 | — | — | |
| SCHEMBL22255955 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4171563-B1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2025-08-06 | — | — | EP | disclosed |
| US-20250092019-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2025-03-20 | — | — | US | disclosed |
| EP-4228755-B1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-12-11 | — | — | EP | disclosed |
| WO-2024240882-A1 | HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR USE IN TREATING ACUTE INFLAMMATION | TES PHARMA S.R.L. (IT) | 2024-11-28 | — | — | WO | disclosed |
| EP-4171571-B1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-10-30 | — | — | EP | disclosed |
| US-20240352033-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-10-24 | — | — | US | disclosed |
| US-20240352032-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-10-24 | — | — | US | disclosed |
| EP-4228756-B1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-06-12 | — | — | EP | disclosed |
| CN-114945408-B | Thienopyrimidinones as TRPA1 inhibitors | 勃林格殷格翰国际有限公司 | 2024-04-16 | — | — | CN | disclosed |
| US-11891403-B2 | Tetrazole derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-02-06 | — | — | US | disclosed |
| CN-103724330-B | The effective combined utilization of monobactams antibiotic and beta-lactamase inhibitor | BASLIER PHARMACEUTICAL AG (CH) | 2015-08-19 | — | — | CN | disclosed |
| CN-100503602-C | Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them | DONGBU HANNONG CHEMICAL CO LTD (KR) | 2009-06-24 | — | — | CN | disclosed |
| US-20080071091-A1 | PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES | WYETH (US) | 2008-03-20 | — | — | US | disclosed |
| US-7323483-B2 | Processes and compounds for the preparation of substituted naphthylindole derivatives | WYETH (US) | 2008-01-29 | — | — | US | disclosed |
| CN-101111491-A | Process and compounds for the preparation of substituted naphthylindole derivatives | WYETH CORP (US) | 2008-01-23 | — | — | CN | disclosed |
| EP-1856104-A1 | PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | disclosed |
| US-20060183917-A1 | Processes and compounds for the preparation of substituted naphthylindole derivatives | WYETH (US) | 2006-08-17 | — | — | US | disclosed |
| WO-2006081455-A1 | PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES | WYETH (US) | 2006-08-03 | — | — | WO | disclosed |
| CN-1646524-A | Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them | DONGBU HANNONG CHEMICAL CO LTD (KR) | 2005-07-27 | — | — | CN | disclosed |
| US-4277479-A | ANTI-ASTHMATIC, HYPOTENSIVE, ANTI-ULCER, ANTIINFLAMMATORY, VASODILATION, ENZYME INHIBITORS, ANTICOAGULANTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-07-07 | — | — | US | disclosed |