Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | RPA1 | P27694 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 2/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996630 | 1.00 | DPP4 (0.38) | DPP4HTR2AGRM2ALDH1A1GRIN2B | |
| Hydrochloric Acid SCHEMBL4831560 | 0.99 | DPP4 (0.37) | DPP4HTR2AGRM2ALDH1A1GRIN2B | |
| Hydrochloric Acid SCHEMBL4831555 | 0.99 | DPP4 (0.37) | DPP4HTR2AGRM2ALDH1A1GRIN2B | |
| SCHEMBL4829751 | 0.90 | TP53 (0.37) | DPP4ALDH1A1GRIN2BNISCHAKT1 | |
| SCHEMBL4829454 | 0.89 | CYP17A1 (0.43) | DPP4GRIN2BDPP8GRIN1 | |
| Hydrochloric Acid SCHEMBL4829583 | 0.89 | TP53 (0.37) | DPP4ALDH1A1GRIN2BAKT1CACNA1B | |
| Hydrochloric Acid SCHEMBL4829588 | 0.89 | TP53 (0.37) | DPP4ALDH1A1GRIN2BAKT1CACNA1B | |
| SCHEMBL4829650 | 0.86 | SLC6A2 (0.42) | DPP4 | |
| SCHEMBL4827824 | 0.85 | DPP4 (0.36) | DPP4HTR2AGRM2ALDH1A1AKT1 | |
| SCHEMBL4829605 | 0.85 | SOS1 (0.40) | DPP4HTR2AKCNH2P2RX7SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-20050059713-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | disclosed |
| WO-2005014534-A1 | ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059713-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | CYP2F1, CYP3A43, PNPO | DPP4 1658/4885HTR2A 3982/4885GRM2 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.