Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.40 |
| ▸ | DPP4 | P27487 | 4/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828915 | 1.00 | PIM1 (0.42) | PIM1EIF2AK4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4820640 | 0.83 | EIF2AK4 (0.46) | PIM1EIF2AK4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL29990018 | 0.83 | PIM1 (0.42) | PIM1EIF2AK4DPP4HRH4DOT1L | |
| SCHEMBL4828737 | 0.83 | CHRNB2 (0.56) | PIM1EIF2AK4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4827828 | 0.83 | CHRNB2 (0.56) | PIM1EIF2AK4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL23497910 | 0.83 | PIM1 (0.42) | PIM1EIF2AK4DPP4HRH4DOT1L | |
| SCHEMBL4826774 | 0.80 | HRH4 (0.47) | HRH4DOT1L | |
| SCHEMBL4819954 | 0.80 | HRH4 (0.47) | HRH4DOT1L | |
| SCHEMBL4827873 | 0.78 | CHRNB2 (0.60) | PIM1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4827625 | 0.78 | CHRNB2 (0.60) | PIM1CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | claimed |
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | disclosed |