Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 1.00 |
| ▸ | GSK3B | P49841 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | MGAM | O43451 | 1/20 | 1.00 |
| ▸ | SI | P14410 | 1/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiazolidinedione SCHEMBL4895522 | 1.00 | — | — | |
| Thiazolidinedione SCHEMBL135101 | 1.00 | — | — | |
| Thiazolidinedione SCHEMBL5043 | 1.00 | — | — | |
| Thiazolidinedione SCHEMBL3294959 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL7844590 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL5795315 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL3294955 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL6789129 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL2331779 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL8522420 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105287604-B | Pharmaceutical composition containing ibat inhibitor and bile acid binding agent | 阿尔比里奥公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-103228270-B | Pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder | ALBIREO AB (SE) | 2016-02-10 | — | — | CN | disclosed |
| CN-105287604-A | A pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder | ALBIREO AB | 2016-02-03 | — | — | CN | disclosed |
| CN-103228270-A | Pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder | ALBIREO AB | 2013-07-31 | — | — | CN | disclosed |
| CN-103221051-A | IBAT inhibitors for treatment of metabolic disorders and related conditions | ALBIREO AB | 2013-07-24 | — | — | CN | disclosed |
| WO-2008111956-A2 | FATTY ACID OXIDATION INHIBITORS TREATING HYPERGLYCEMIA AND RELATED DISORDERS | SYMCOPEIA COMPANY (US) | 2008-09-18 | — | — | WO | disclosed |
| EP-1865945-A4 | COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES | HONG KONG NITRIC OXIDE LTD (CN) | 2008-05-21 | — | — | EP | disclosed |
| EP-1865945-A1 | COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES | Hong Kong Nitric Oxide Limited (CN) | 2007-12-19 | — | — | EP | disclosed |
| WO-2007049050-A2 | MODULATORS OF GPR40 FOR THE TREATMENT OF DIABETES | HEPTAHELIX AB (SE) | 2007-05-03 | — | — | WO | disclosed |
| WO-2006099244-A1 | COMBINATION THERAPY FOR ENDOTHELIAL DYSFUNCTION, ANGINA AND DIABETES | HONG KONG NITRIC OXIDE LIMITED (CN) | 2006-09-21 | — | — | WO | disclosed |
| CN-1194140-A | Medicine | LILLY CO ELI (US) | 1998-09-30 | — | — | CN | disclosed |