⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiazolidinedione SCHEMBL135101 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL4895522 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL4828229 | 0.97 | GSK3A (1.00) | — | |
| Thiazolidinedione SCHEMBL5043 | 0.97 | — | — | |
| Thiazolidinedione SCHEMBL3294955 | 0.94 | — | — | |
| Thiazolidinedione SCHEMBL3294959 | 0.94 | — | — | |
| Thiazolidinedione SCHEMBL5795315 | 0.94 | — | — | |
| Thiazolidinedione SCHEMBL6789129 | 0.94 | — | — | |
| Thiazolidinedione SCHEMBL2331779 | 0.94 | — | — | |
| Thiazolidinedione SCHEMBL8522420 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5885997-A | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-03-23 | — | — | US | claimed |
| CN-1123570-C | Method of preparing benzothiophene derivative | HOFFMANN LA ROCHE (CH) | 2003-10-08 | — | — | CN | disclosed |
| EP-0767790-B1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| CN-1282741-A | Method of preparing benzothiophene derivative | HOFFMANN LA ROCHE (CH) | 2001-02-07 | — | — | CN | disclosed |
| CN-1046725-C | fused imidazole compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-11-24 | — | — | CN | disclosed |
| US-5840732-A | ANTIDIABETIC AGENTS, AUTOIMMUNE DISEASES OR IMMUNOSUPPRESSANTS | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| CN-1151161-A | fused imidazole compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-06-04 | — | — | CN | disclosed |
| EP-0767790-A1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-04-16 | — | — | EP | disclosed |
| WO-1995035296-A1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-12-28 | — | — | WO | disclosed |
| CN-1003445-B | thiazolidinedione derivatives, their preparation and use | 武田药品工业株式会社 | 1989-03-01 | — | — | CN | disclosed |
| CN-85107870-A | The preparation method of thiazolidine diketone derivative and purposes | — | 1986-07-16 | — | — | CN | disclosed |
| US-4411901-A | ANTIPSYCHOTICS | MEAD JOHNSON & COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4367335-A | PSYCHOLOGICAL DISORDERS | MEAD JOHNSON & COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4207236-A | 3-(tert-Alkylthio)-1,3-thiazolidin-2,4-dione | MONSANTO COMPANY (US) | 1980-06-10 | — | — | US | disclosed |
| US-4165417-A | 3-(Tert-alkylthio)-1,3-thiazolidin-2,4-dione used to inhibit premature vulcanization of diene rubbers | MONSANTO COMPANY (US) | 1979-08-21 | — | — | US | disclosed |