Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828338 | 1.00 | KDM4E (0.36) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4757713 | 0.93 | KDM4E (0.32) | KDM4EHTTATMCYP2E1JAK2 | |
| SCHEMBL4823086 | 0.93 | CYP2E1 (0.36) | PDE4DSYKCYP2E1JAK2JAK3 | |
| SCHEMBL4823092 | 0.93 | CYP2E1 (0.36) | PDE4DSYKCYP2E1JAK2JAK3 | |
| Ammonia Solution, Strong SCHEMBL4819219 | 0.92 | CYP2E1 (0.36) | SYKCYP2E1JAK2JAK3 | |
| Ammonia Solution, Strong SCHEMBL4819230 | 0.92 | CYP2E1 (0.36) | SYKCYP2E1JAK2JAK3 | |
| SCHEMBL4155399 | 0.91 | KDM4E (0.38) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4155397 | 0.91 | KDM4E (0.38) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4824077 | 0.90 | KDM4E (0.36) | KDM4EHTTATMPDE4DSYK | |
| SCHEMBL4824071 | 0.90 | KDM4E (0.36) | KDM4EHTTATMPDE4DSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000818-A1 | 3-CARBONYLAMINOTHIOPHENE-2-CARBOXYLIC ACIDS AS HEPATITIS C VIRUS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-31 | — | — | WO | disclosed |