⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754501 | 0.75 | ALDH1A1 (0.47) | — | |
| SCHEMBL11577666 | 0.74 | — | — | |
| SCHEMBL1451269 | 0.74 | TSHR (0.35) | — | |
| SCHEMBL4600158 | 0.73 | — | — | |
| SCHEMBL197458 | 0.73 | — | — | |
| SCHEMBL4599434 | 0.73 | — | — | |
| SCHEMBL4425991 | 0.72 | KDM5A (0.33) | — | |
| SCHEMBL4838147 | 0.70 | CA1 (0.35) | — | |
| SCHEMBL11028485 | 0.69 | CA1 (0.46) | — | |
| SCHEMBL8721665 | 0.69 | GAA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402589-B2 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2008-07-22 | — | — | US | claimed |
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-03 | — | — | US | claimed |
| CN-113683522-A | Preparation method of N-methyltyramine hydrochloride | 广汉市派瑞林科技有限责任公司 | 2021-11-23 | — | — | CN | disclosed |
| CN-103113244-B | Preparation method of synephrine derivative capable of being absorbed through skin | HUNAN XINLI BIOLOG SCIENCE & TECHNOLOGY CO LTD | 2015-06-03 | — | — | CN | disclosed |
| CN-103113244-A | Preparation method of synephrine derivative capable of being absorbed through skin | HUNAN XINLI BIOLOG SCIENCE & TECHNOLOGY CO LTD | 2013-05-22 | — | — | CN | disclosed |
| US-7402589-B2 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2008-07-22 | — | — | US | disclosed |
| CN-1946700-A | Trisubstituted ureas as cytokine inhibitors | PROCTER & GAMBLE (US) | 2007-04-11 | — | — | CN | disclosed |
| EP-1737830-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | The Procter and Gamble Company (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005105757-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-03 | — | — | US | disclosed |