SCHEMBL483004

SCHEMBL483004

Cc1cc(=O)oc2cc(C(N)=O)ccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.61
ALDH1A1 P00352 9/20 0.61
GLA P06280 6/20 0.61
HPGD P15428 6/20 0.61
HSD17B10 Q99714 6/20 0.61
GAA P10253 5/20 0.61
CA9 Q16790 5/20 0.61
CA12 O43570 4/20 0.61
CA1 P00915 4/20 0.61
CASP1 P29466 3/20 0.61
CASP7 P55210 3/20 0.61
AKR1B1 P15121 2/20 0.61
MCL1 Q07820 2/20 0.61
LMNA P02545 1/20 0.61
CYP1A2 P05177 1/20 0.61
CYP2C9 P11712 1/20 0.61
UGT1A1 P22309 1/20 0.61
MAOB P27338 1/20 0.61
KDR P35968 1/20 0.61
HSD17B3 P37058 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29403594 1.00 KDM4E (0.61) KDM4EALDH1A1GLAHPGDHSD17B10
Hydrochloric Acid SCHEMBL30656908 0.98 KDM4E (0.59) KDM4EALDH1A1GLAHPGDHSD17B10
Trifluoroacetic Acid SCHEMBL14844335 0.90 KDM4E (0.53) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL17885121 0.85 ALDH1A1 (0.63) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL27587553 0.81 KDM4E (0.59) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL8410573 0.81 KDM4E (0.50) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL4386398 0.80 KDM4E (0.56) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL27771200 0.80 ALDH1A1 (0.64) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL31693361 0.79 ALDH1A1 (0.62) KDM4EALDH1A1GLAHPGDHSD17B10
SCHEMBL8594112 0.78 HSD17B3 (0.66) KDM4EALDH1A1HPGDHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1510136-A Enzyme 阿克雷株式会社 2004-07-07 CN claimed
CN-1340099-A Novel enzymes ACLAY CO LTD (JP) 2002-03-13 CN claimed
EP-0304871-A2 Dental diagnostic device and method DENTSPLY MANAGEMENT CORP. (US) 1989-03-01 EP claimed
JP-10313896-A None JP disclosed
WO-2025089217-A1 COMPOUND FOR USE AS SUBSTRATE FOR EVALUATING ACTIVITY OF γ-D-GLUTAMYL-L-LYSYL ENDOPEPTIDASE 株式会社ヤクルト本社 2025-05-01 WO disclosed
CN-119192121-A Human cathepsin S inhibitor and application thereof 北京谱峰源生物科技有限公司 2024-12-27 CN disclosed
CN-118786120-A Compounds and their use for the treatment of diseases associated with impaired beta-galactosidase activity 多尔潘股份公司 2024-10-15 CN disclosed
CN-114341154-B Substrate for measuring tryptase activity 国立大学法人东京农工大学 2024-07-30 CN disclosed
CN-111655852-B Aptamer for chymase and application thereof 力博美科股份有限公司 2024-06-25 CN disclosed
US-20230266316-A1 Somatostatin Receptor RIKEN BIO CO. LTD. (JP) 2023-08-24 US disclosed
CN-114890856-B Method for synthesizing 2,2' -biphenyl-1-carboxylic acid derivative 华南理工大学 2023-08-22 CN disclosed
EP-0476715-A2 Method and composition for the determination of chloride ions in fluids THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA (AU) 1992-03-25 EP disclosed
EP-0471391-A2 Determination of ions in fluids THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA (AU) 1992-02-19 EP disclosed
US-5053333-A Specific for pared basic amino acid residues M & D RESEARCH CO., LTD. (JP) 1991-10-01 US disclosed
EP-0445304-A1 ISOLATED, PHYSIOLOGICALLY ACTIVE HUMAN THROMBOMODULIN POLYPEPTIDE Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-09-11 EP disclosed
EP-0336056-A1 Protease M & D RESEARCH CO., LTD. (JP) 1989-10-11 EP disclosed
EP-0309525-A1 DETERMINATION OF IONS IN FLUIDS THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA (AU) 1989-04-05 EP disclosed
EP-0304871-A2 Dental diagnostic device and method DENTSPLY MANAGEMENT CORP. (US) 1989-03-01 EP disclosed
WO-1988008137-A1 DETERMINATION OF IONS IN FLUIDS THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA (AU) 1988-10-20 WO disclosed
EP-0286039-A2 Determination of potassium ions in fluids THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA (AU) 1988-10-12 EP disclosed