Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 3/20 | 0.32 |
| ▸ | KDM4B | O94953 | 3/20 | 0.32 |
| ▸ | KDM5C | P41229 | 3/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.32 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4825624 | 0.79 | CA12 (0.35) | KDM4ESRPK1RPS6KB2KDM4AKDM5C | |
| SCHEMBL4828066 | 0.77 | GAA (0.34) | KDM4ENPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL4831483 | 0.77 | SMN1; SMN2 (0.36) | KDM4ETDP1SRPK1RPS6KB2KDM4A | |
| SCHEMBL3244153 | 0.71 | SRD5A2 (0.43) | KDM4ERAB9AKDM4AKDM5BFGFR1 | |
| SCHEMBL4830030 | 0.70 | SLC22A12 (0.35) | RPS6KA2MAPKAPK2CSNK2A1RPS6KA3 | |
| SCHEMBL4826413 | 0.68 | MAPK8 (0.34) | KDM4ETDP1L3MBTL1KDM4AKDM4B | |
| SCHEMBL4829827 | 0.67 | RPS6KA3 (0.41) | RPS6KA2FGFR1MAPKAPK2RPS6KA3 | |
| SCHEMBL3092075 | 0.64 | SRPK1 (0.34) | SRPK1RPS6KB2MAPKAPK2CSNK2A1RPS6KA3 | |
| SCHEMBL3075059 | 0.64 | TBXA2R (0.36) | KDM4EHSD17B10ALDH1A1HPGDACLY | |
| SCHEMBL4823474 | 0.62 | POLB (0.36) | KDM4ERAB9AKDM4AKDM5CFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348425-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| US-7153848-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060166964-A1 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY | 2006-07-27 | — | — | US | disclosed |
| US-20060046983-A1 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166964-A1 | Inhibitors of HCV replication | EIF2AK2, HCCS, IDO1 | KDM4E 2251/4885NPC1 731/4885RAB9A 2098/4885 |
| US-20060046983-A1 | Inhibitors of HCV replication | EIF2AK2, HCCS, IDO1 | KDM4E 2251/4885NPC1 731/4885RAB9A 2098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.