Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.65 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4231389 | 0.88 | AQP1 (0.71) | AQP1HTR2AHTR2CHRH1EZH2 | |
| SCHEMBL4220492 | 0.88 | AQP1 (0.71) | AQP1HTR2AHTR2CHRH1EZH2 | |
| SCHEMBL4788915 | 0.85 | AQP1 (0.53) | AQP1HTR2AHTR2CHRH1EZH2 | |
| SCHEMBL4968896 | 0.84 | AQP1 (0.43) | AQP1HTR2AHTR2CHRH1PRKAB2 | |
| SCHEMBL4837073 | 0.83 | AQP1 (0.44) | AQP1HTR2AHTR2CHRH1PRKAB2 | |
| SCHEMBL13911343 | 0.82 | AQP1 (0.76) | AQP1EZH2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4966046 | 0.81 | AQP1 (0.48) | AQP1HTR2AHTR2CPRKAB2PRKAG1 | |
| SCHEMBL4965176 | 0.81 | AQP1 (0.41) | AQP1HTR2AHTR2CPRKAB2PRKAG1 | |
| SCHEMBL4596829 | 0.80 | AQP1 (0.58) | AQP1 | |
| SCHEMBL8254836 | 0.79 | AQP1 (0.72) | AQP1HTR2AHTR2CEZH2PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871356-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116170-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |