Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 6/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | CLK2 | P49760 | 3/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831089 | 0.83 | BCAT1 (0.41) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL4831070 | 0.81 | BCAT1 (0.40) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL4829590 | 0.81 | CDC7 (0.51) | LRRK2BCAT1PIM1PDPK1MAP4K4 | |
| SCHEMBL4827516 | 0.80 | BCAT1 (0.39) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL4831524 | 0.80 | BCAT1 (0.47) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL8290897 | 0.79 | BCAT1 (0.41) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL8290902 | 0.79 | LRRK2 (0.44) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL4824517 | 0.78 | LRRK2 (0.42) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL4827673 | 0.77 | BCAT1 (0.42) | LRRK2BCAT1PIM1PIM3PIM2 | |
| SCHEMBL8290699 | 0.77 | BRD4 (0.42) | LRRK2BCAT1PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | LRRK2 483/4885BCAT1 1341/4885PIM1 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.