Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726177 | 0.93 | CDK2 (0.47) | CDK4CDK2PLK1FAAHAURKA | |
| SCHEMBL4801761 | 0.91 | CDK2 (0.50) | CDK4CDK2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL4725761 | 0.90 | AURKA (0.51) | CDK4CDK2PLK1FAAHAURKA | |
| SCHEMBL4727456 | 0.89 | AURKA (0.52) | CDK2PIK3CAPIK3CBPIK3CGPLK1 | |
| SCHEMBL14293018 | 0.88 | ALDH1A1 (0.54) | CDK4CDK2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL4838019 | 0.88 | STK17A (0.49) | STK17ACDK4CDK2PLK1FAAH | |
| SCHEMBL14292059 | 0.87 | EGFR (0.52) | STK17ACDK4CDK2PIK3CAPIK3CB | |
| SCHEMBL4880977 | 0.85 | AURKA (0.54) | STK17ACDK4CDK2FAAHAURKA | |
| SCHEMBL4797527 | 0.84 | AURKA (0.49) | CDK4CDK2FAAHAURKAMAPK8 | |
| SCHEMBL14293019 | 0.84 | KDR (0.44) | CDK4CDK2PLK1FAAHAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |