Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | MARK3 | P27448 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | FRK | P42685 | 3/20 | 0.46 |
| ▸ | CLK2 | P49760 | 3/20 | 0.46 |
| ▸ | NEK4 | P51957 | 3/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.46 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.46 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.46 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.46 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832788 | 0.85 | DYRK1A (0.39) | PRKD3MAP4K4CDK1MARK3FLT4 | |
| SCHEMBL4831605 | 0.84 | NTRK1 (0.47) | DYRK1AAXLNTRK1KITPDPK1 | |
| SCHEMBL4831036 | 0.84 | MAPK1 (0.45) | PRKD3MAP4K4CDK1MARK3FLT4 | |
| SCHEMBL4832730 | 0.83 | CDK2 (0.45) | MAP4K4CDK1CLK4IRAK4STK17A | |
| SCHEMBL4831383 | 0.82 | DYRK1A (0.49) | MAP4K4CLK4IRAK4DYRK1AROCK2 | |
| SCHEMBL4829553 | 0.81 | MAPK8 (0.50) | DYRK1AMAPK8AXLNTRK1MAPK9 | |
| SCHEMBL984208 | 0.79 | ALDH1A1 (0.35) | HCAR1ALDH1A1 | |
| SCHEMBL4824548 | 0.79 | MAP4K1 (0.43) | DYRK1AAXLALKKITCDK8 | |
| SCHEMBL4829240 | 0.78 | MAP4K1 (0.52) | AXLPIM1 | |
| SCHEMBL4827257 | 0.78 | MAP4K1 (0.53) | FLT3DYRK1ARPS6KA3TNIKCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | PRKD3 84/4885MAP4K4 45/4885CDK1 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.