Tirilazad

Tirilazad

SCHEMBL483318

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 3/20 1.00
HTR2B P41595 3/20 1.00
KCNH2 Q12809 2/20 1.00
AR P10275 2/20 1.00
LCK P06239 2/20 1.00
FYN P06241 2/20 1.00
ADORA3 P0DMS8 2/20 1.00
MAPK3 P27361 2/20 1.00
HTR2C P28335 2/20 1.00
DRD3 P35462 2/20 1.00
MAPK14 Q16539 2/20 1.00
EGFR P00533 1/20 1.00
ADRB2 P07550 1/20 1.00
CHRM2 P08172 1/20 1.00
ADRA2A P08913 1/20 1.00
ADRA2C P18825 1/20 1.00
DRD1 P21728 1/20 1.00
PTGS1 P23219 1/20 1.00
HRH2 P25021 1/20 1.00
PDE4A P27815 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tirilazad SCHEMBL25994341 1.00 PGR (1.00) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL4938280 1.00 PGR (1.00) PGRHTR2BKCNH2ARLCK
SCHEMBL9134229 1.00 PGR (1.00) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL9073226 0.99 PGR (0.99) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL9073229 0.99 PGR (0.99) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL10695568 0.97 KCNH2 (0.93) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL9724980 0.97 KCNH2 (0.93) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL1650168 0.97 KCNH2 (0.93) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL9069954 0.97 KCNH2 (0.93) PGRHTR2BKCNH2ARLCK
Tirilazad SCHEMBL9221827 0.97 KCNH2 (0.93) PGRHTR2BKCNH2ARLCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
US-12296043-B2 Liquisoft capsules PATHEON SOFTGELS INC. (US) 2025-05-13 US claimed
EP-4510999-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS Bristol-Myers Squibb Company (US) 2025-02-26 EP claimed
EP-3274008-B1 DETECTION OF BRAIN INJURY THE UNIV OF MONTANA (US) 2024-12-04 EP claimed
WO-2024124354-A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PAIN OR OTHER DISORDERS AIMA INC. (CA) 2024-06-20 WO claimed
US-20240165020-A1 LIQUISOFT CAPSULES PATHEON SOFTGELS INC (US) 2024-05-23 US claimed
EP-4360653-A2 LIQUISOFT CAPSULES Patheon Softgels Inc. (US) 2024-05-01 EP claimed
US-11872307-B2 Liquisoft capsules PATHEON SOFTGELS INC. (US) 2024-01-16 US claimed
EP-3682872-B1 LIQUISOFT CAPSULES PATHEON SOFTGELS INC (US) 2024-01-03 EP claimed
WO-2023205619-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2023-10-26 WO claimed
WO-1995031194-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1995-11-23 WO claimed
EP-0238545-B1 C20 THROUGH C26 AMINO STEROIDS UPJOHN CO (US) 1995-11-15 EP claimed
EP-0674528-A1 CYCLODEXTRIN AND POLYMER BASED DRUG DELIVERY SYSTEM INSITE VISION INCORPORATED (US) 1995-10-04 EP claimed
EP-0263213-B1 C20 Through C26 amino steroids UPJOHN CO (US) 1995-09-06 EP claimed
US-5332582-A Lightly crosslinked carboxy-containing polymers INSITE VISION INCORPORATED (US) 1994-07-26 US claimed
WO-1994012217-A1 CYCLODEXTRIN AND POLYMER BASED DRUG DELIVERY SYSTEM INSITE VISION INCORPORATED (US) 1994-06-09 WO claimed
US-5175281-A Antiulcer, antiinflammatory, antiischemic, antiallergen, antisecretory, wound healing agents; cardiovascular disorders THE UPJOHN COMPANY (US) 1992-12-29 US claimed
EP-0263213-A1 C20 Through C26 amino steroids THE UPJOHN COMPANY (US) 1988-04-13 EP claimed
EP-0238545-A1 C 20? THROUGH C 26? AMINO STEROIDS. UPJOHN CO (US) 1987-09-30 EP claimed
WO-1987001706-A2 C20 THROUGH C26 AMINO STEROIDS THE UPJOHN COMPANY (US) 1987-03-26 WO claimed