Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.72 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.67 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.67 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.67 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.67 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.67 |
| ▸ | STK36 | Q9NRP7 | 1/20 | 0.67 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832255 | 0.89 | MAPK14 (0.74) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL4828155 | 0.87 | MAPK8 (0.67) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL29593473 | 0.84 | MAPK14 (1.00) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL14410870 | 0.84 | MAPK8 (0.63) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL4899133 | 0.84 | MAPK8 (0.69) | MAPK8 | |
| SCHEMBL5122374 | 0.84 | MAPK14 (1.00) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL14280048 | 0.83 | MAPK8 (0.74) | MAPK14MAPK8 | |
| SCHEMBL14014575 | 0.82 | MAPK14 (1.00) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL14014544 | 0.82 | MAPK8 (0.84) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL14014547 | 0.82 | MAPK14 (0.83) | MAPK14MAPK8GAKRPS6KA4PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320987-B2 | 6-Alkoxy-pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1539755-B1 | 6-ALKOXY-PYRIDO-PYRIMIDINES AS P-38 MAP KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2007-09-26 | — | — | EP | disclosed |
| US-20070167484-A1 | 6-Alkoxy-pyrido-pyrimidines | GOLDSTEIN DAVID M | 2007-07-19 | — | — | US | disclosed |
| US-7196097-B2 | 6-alkoxy-pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-03-27 | — | — | US | disclosed |
| US-20060276646-A1 | 6-alkoxy-pyrido-pyrimidines | GOLDSTEIN DAVID M | 2006-12-07 | — | — | US | disclosed |
| US-7105525-B2 | 6-alkoxy-pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2006-09-12 | — | — | US | disclosed |
| US-6965030-B2 | 6-alkoxy-pyrido-pyridine | ROCHE PALO ALTO LLC (US) | 2005-11-15 | — | — | US | disclosed |
| US-20050203300-A1 | 6-Alkoxy-pyrido-pyrimidines | GOLDSTEIN DAVID M (US) | 2005-09-15 | — | — | US | disclosed |
| US-20040038999-A1 | 6-alkoxy-pyrido-pyrimidines | ROCHE PALO ALTO LLC | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038999-A1 | 6-alkoxy-pyrido-pyrimidines | CYP2B6, CYP2D6, CNR1 | MAPK14 4498/4885MAPK8 4373/4885GAK 1098/4885 |
| US-20060276646-A1 | 6-alkoxy-pyrido-pyrimidines | PDXK, PNPO, CYP2D6 | MAPK14 4426/4885MAPK8 4307/4885GAK 193/4885 |
| US-20050203300-A1 | 6-Alkoxy-pyrido-pyrimidines | CCNO, CCNY, PNPO | MAPK14 4398/4885MAPK8 4351/4885GAK 1129/4885 |
| US-20070167484-A1 | 6-Alkoxy-pyrido-pyrimidines | CCNO, PNPO, CYP2B6 | MAPK14 4565/4885MAPK8 4288/4885GAK 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.