Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 9/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | HPD | P32754 | 1/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483225 | 1.00 | SCN3A (0.39) | SCN3AF2F10BTKKCNH2 | |
| SCHEMBL483533 | 0.95 | F2 (0.39) | SCN3AF2F10BTKKCNH2 | |
| SCHEMBL484165 | 0.91 | SCN3A (0.48) | SCN3ABTKKCNH2SCN1ASCN4A | |
| SCHEMBL483702 | 0.91 | SCN3A (0.48) | SCN3ABTKKCNH2SCN1ASCN4A | |
| SCHEMBL2834518 | 0.89 | HPD (0.42) | SCN3AF2F10KCNH2HPD | |
| SCHEMBL2835406 | 0.89 | HPD (0.42) | SCN3AF2F10KCNH2HPD | |
| SCHEMBL483562 | 0.86 | KCNH2 (0.48) | SCN3ABTKKCNH2SCN1ASCN4A | |
| SCHEMBL310836 | 0.86 | KCNH2 (0.48) | SCN3ABTKKCNH2SCN1ASCN4A | |
| SCHEMBL483745 | 0.85 | BTK (0.40) | SCN3AF2F10BTKKCNH2 | |
| SCHEMBL2832474 | 0.83 | KCNH2 (0.42) | SCN3AF2F10KCNH2HPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |