Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483668 | 0.88 | KCNH2 (0.53) | KCNH2SCN3APRMT5PARP15PARP10 | |
| SCHEMBL310676 | 0.86 | KCNH2 (0.54) | KCNH2SCN3APARP15PARP10SCN1A | |
| SCHEMBL483795 | 0.86 | KCNH2 (0.54) | KCNH2SCN3APARP15PARP10SCN1A | |
| SCHEMBL2835713 | 0.83 | KCNH2 (0.61) | KCNH2SCN3APRMT5PARP15PARP10 | |
| SCHEMBL2833224 | 0.78 | KCNH2 (0.57) | KCNH2SCN3APRMT5PARP15PARP10 | |
| SCHEMBL2837170 | 0.78 | KCNH2 (0.57) | KCNH2SCN3APRMT5PARP15PARP10 | |
| SCHEMBL483579 | 0.78 | KCNH2 (0.56) | KCNH2SCN3APRMT5PARP15PARP10 | |
| SCHEMBL2837757 | 0.75 | KCNH2 (0.55) | KCNH2SCN3APRMT5PARP15PARP10 | |
| SCHEMBL483295 | 0.75 | KCNH2 (0.51) | KCNH2SCN3APARP15PARP10SCN1A | |
| SCHEMBL2839989 | 0.75 | KCNH2 (0.54) | KCNH2SCN3APRMT5PARP15PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |