Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 10/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | SCN4A | P35499 | 1/20 | 0.49 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310676 | 1.00 | KCNH2 (0.54) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL311657 | 0.88 | KCNH2 (0.46) | KCNH2MAOBPARP10OPRM1OPRD1 | |
| SCHEMBL483408 | 0.88 | KCNH2 (0.46) | KCNH2MAOBPARP10OPRM1OPRD1 | |
| SCHEMBL483784 | 0.86 | KCNH2 (0.51) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL483581 | 0.86 | KCNH2 (0.55) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL483295 | 0.86 | KCNH2 (0.51) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2832873 | 0.80 | KCNH2 (0.59) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2832497 | 0.80 | KCNH2 (0.59) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL310423 | 0.80 | KCNH2 (0.56) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL840054 | 0.80 | KCNH2 (0.56) | KCNH2SCN3ASCN9ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |