Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412790 | 0.89 | NPSR1 (0.41) | NPSR1LTB4RHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL413515 | 0.83 | EGFR (0.43) | NPSR1LTB4RKMT2APOLBGAA | |
| SCHEMBL410256 | 0.83 | NPC1 (0.40) | NPSR1LTB4RALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13041260 | 0.82 | NPSR1 (0.50) | NPSR1LTB4RHPGDALDH1A1KDM4E | |
| SCHEMBL3300296 | 0.79 | NPSR1 (0.43) | NPSR1LTB4RHPGDALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL4629522 | 0.79 | NPSR1 (0.41) | NPSR1LTB4RHPGDALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL411516 | 0.78 | NPSR1 (0.42) | NPSR1LTB4RHPGDALDH1A1KDM4E | |
| SCHEMBL14401731 | 0.77 | NPSR1 (0.39) | NPSR1LTB4RHPGDALDH1A1KDM4E | |
| SCHEMBL3303665 | 0.77 | NPC1 (0.39) | NPSR1HPGDALDH1A1KDM4ECYP1A2 | |
| SCHEMBL411454 | 0.76 | POLB (0.43) | NPSR1LTB4RHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919881-A1 | 1, 2, 3 -TRIAZOLES INHIBITORS OF TUBULIN POLYMERIZATION FOR THE TREATMENT OF POLIFERATIVE DISORDERS | Synta Pharmaceuticals Corporation (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007014198-A1 | 1, 2, 3 -TRIAZOLES INHIBITORS OF TUBULIN POLYMERIZATION FOR THE TREATMENT OF POLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-01 | — | — | WO | disclosed |