Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | EBP | Q15125 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL27719094 | 0.99 | KMT2A (0.36) | KMT2AKDM1AHSD11B1EBPSIGMAR1 | |
| SCHEMBL27719092 | 0.72 | KMT2A (0.34) | KMT2AKDM1AEBPSIGMAR1TMEM97 | |
| SCHEMBL5567608 | 0.68 | KMT2A (0.42) | KMT2ASIGMAR1MEN1 | |
| SCHEMBL1494053 | 0.67 | KDM4E (0.36) | KMT2AKDM4E | |
| SCHEMBL12832326 | 0.67 | ALDH1A1 (0.33) | KMT2AKDM1AKDM4E | |
| Iodide SCHEMBL1494123 | 0.66 | ALDH1A1 (0.32) | KMT2A | |
| SCHEMBL1494089 | 0.65 | HTR2A (0.44) | KMT2AMEN1KDM4E | |
| SCHEMBL1494045 | 0.64 | ALDH1A1 (0.45) | KMT2AMEN1CAPN1KDM4ETDP1 | |
| SCHEMBL8590736 | 0.63 | CYP1A1 (0.35) | KMT2AMEN1KDM4ETDP1 | |
| SCHEMBL27656327 | 0.63 | KMT2A (0.34) | KMT2AKDM1ASIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924264-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025925-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |