Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31717971 | 0.84 | MEN1 (0.41) | KDM4ENPSR1ALDH1A1POLBMEN1 | |
| SCHEMBL28704414 | 0.84 | COMT (0.40) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL28690729 | 0.74 | KDM4E (0.41) | KDM4EPKMSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL29915861 | 0.74 | MEN1 (0.44) | NPSR1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL208852 | 0.74 | MEN1 (0.44) | NPSR1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL17074881 | 0.73 | MEN1 (0.44) | KDM4EPKMSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL281760 | 0.73 | SCN9A (0.53) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL28692040 | 0.72 | HDAC4 (0.41) | KDM4ESMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL28703009 | 0.71 | ESR1 (0.35) | KDM4EPKMSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL28704411 | 0.70 | KDM4E (0.38) | KDM4EPKMSMN1; SMN2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |