Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.72 |
| ▸ | SCN3A | Q9NY46 | 7/20 | 0.62 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.50 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.50 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093299 | 1.00 | KCNH2 (0.72) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL310295 | 0.94 | KCNH2 (0.82) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL310303 | 0.94 | KCNH2 (0.82) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL2836386 | 0.87 | KCNH2 (0.58) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL2839975 | 0.84 | KCNH2 (1.00) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL17873393 | 0.83 | KCNH2 (0.66) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL24279500 | 0.83 | KCNH2 (0.79) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| Hydrochloric Acid SCHEMBL2836853 | 0.83 | KCNH2 (0.98) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL2835344 | 0.82 | KCNH2 (0.77) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| Hydrochloric Acid SCHEMBL2837163 | 0.81 | KCNH2 (0.76) | KCNH2SCN3AFFAR2SCN9ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |