Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.82 |
| ▸ | SCN3A | Q9NY46 | 7/20 | 0.58 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN4A | P35499 | 1/20 | 0.52 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310303 | 1.00 | KCNH2 (0.82) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL483699 | 0.94 | KCNH2 (0.72) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL1093299 | 0.94 | KCNH2 (0.72) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL2839975 | 0.90 | KCNH2 (1.00) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL24279500 | 0.89 | KCNH2 (0.79) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| Hydrochloric Acid SCHEMBL2836853 | 0.89 | KCNH2 (0.98) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL17873393 | 0.89 | KCNH2 (0.66) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL2835344 | 0.88 | KCNH2 (0.77) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| Hydrochloric Acid SCHEMBL2837163 | 0.87 | KCNH2 (0.76) | KCNH2SCN3AFFAR2SCN9ASCN1A | |
| SCHEMBL12079896 | 0.87 | KCNH2 (0.66) | KCNH2SCN3AFFAR2SCN9ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237379-B1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES | CONVERGENCE PHARMACEUTICALS (GB) | 2022-04-06 | — | — | EP | disclosed |
| US-10421716-B2 | Process for preparing alpha-carboxamide pyrrolidine derivatives | Convergence Pharmaceuticals Limited (GB) | 2019-09-24 | — | — | US | disclosed |
| US-20170369437-A1 | Process for Preparing Alpha-Carboxamide Pyrrolidine Derivatives | Convergence Pharmaceuticals Limited (GB) | 2017-12-28 | — | — | US | disclosed |
| EP-3237379-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES | Convergence Pharmaceuticals Limited (GB) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016102967-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES | Convergence Pharmaceuticals Limited (GB) | 2016-06-30 | — | — | WO | disclosed |
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| US-8153681-B2 | Method of treating epilepsy by administering 5-(4{[(2-fluorophenyl)methyl]oxy}phenyl)prolinamide | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| US-8143306-B2 | Methods of treating bipolar disorders | Convergence Pharmaceuticals Limited (GB) | 2012-03-27 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |
| US-8093268-B2 | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) | GLAXO GROUP LIMITED (GB) | 2012-01-10 | — | — | US | disclosed |
| EP-2117535-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS | GLAXO GROUP LTD (GB) | 2011-10-26 | — | — | EP | disclosed |
| EP-2117562-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS | GLAXO GROUP LTD (GB) | 2011-10-26 | — | — | EP | disclosed |
| US-20110098335-A1 | NOVEL COMPOUNDS | Convergence Pharmaceuticals Limited (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20100113521-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-(2S-PHENYLPIPERIDIN-3S-YL-) | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098335-A1 | NOVEL COMPOUNDS | SCN1A, SCN1B, SCNN1B | KCNH2 65/4885SCN3A 8/4885FFAR2 459/4885 |
| US-20100113521-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-(2S-PHENYLPIPERIDIN-3S-YL-) | KCNJ2, TRPV1, SCN5A | KCNH2 11/4885SCN3A 40/4885FFAR2 314/4885 |
| US-10421716-B2 | Process for preparing alpha-carboxamide pyrrolidine derivatives | CPS1, ALDH18A1, PCCA | KCNH2 732/4885SCN3A 2354/4885FFAR2 1264/4885 |
| US-20170369437-A1 | Process for Preparing Alpha-Carboxamide Pyrrolidine Derivatives | CPS1, ALDH18A1, PCCA | KCNH2 732/4885SCN3A 2354/4885FFAR2 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.