Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.56 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.52 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462231 | 0.87 | GRIK1 (0.72) | GRIK1KDM4EMEN1KMT2ATAS2R14 | |
| SCHEMBL6438520 | 0.81 | GRIK1 (0.81) | GRIK1KDM4EMEN1KMT2ATRPV1 | |
| SCHEMBL3962623 | 0.81 | GRIK1 (1.00) | GRIK1MEN1KMT2A | |
| SCHEMBL422330 | 0.78 | TSHR (0.57) | GRIK1MEN1KMT2APDK1PDK2 | |
| SCHEMBL7820305 | 0.78 | SMN1; SMN2 (0.70) | GRIK1KDM4EMEN1KMT2ATAS2R14 | |
| SCHEMBL7759976 | 0.77 | MEN1 (0.68) | GRIK1KDM4EMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2990630 | 0.77 | TSHR (0.55) | GRIK1MEN1KMT2APDK1PDK2 | |
| SCHEMBL6439621 | 0.77 | GRIK1 (0.63) | GRIK1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6440417 | 0.76 | GRIK1 (0.62) | GRIK1KDM4EMEN1KMT2ATAS2R14 | |
| SCHEMBL27704223 | 0.75 | RXFP1 (0.56) | KDM4EMEN1KMT2ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008234-A1 | 2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-17 | — | — | WO | disclosed |