Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280946 | 0.80 | SCN9A (0.34) | SCN9AIRAK4 | |
| SCHEMBL280671 | 0.77 | POLB (0.44) | SCN9AALDH1A1 | |
| SCHEMBL282084 | 0.76 | SCN9A (0.37) | SCN9AALDH1A1 | |
| SCHEMBL328298 | 0.72 | ALDH1A1 (0.41) | SCN9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL281527 | 0.69 | SCN9A (0.47) | SCN9A | |
| SCHEMBL280729 | 0.69 | SCN9A (0.35) | SCN9AALDH1A1 | |
| SCHEMBL281207 | 0.65 | POLB (0.40) | SCN9AIRAK4ALDH1A1 | |
| SCHEMBL280951 | 0.65 | POLB (0.44) | SCN9AALDH1A1HSD17B10 | |
| SCHEMBL2305420 | 0.65 | SCN9A (0.40) | SCN9AALDH1A1 | |
| SCHEMBL280856 | 0.63 | SCN9A (0.50) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |