Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 3/20 | 0.40 |
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834932 | 0.95 | ADORA2A (0.46) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4843809 | 0.89 | CHEK2 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4834799 | 0.86 | PLG (0.43) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13607862 | 0.86 | HDAC6 (0.41) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4839519 | 0.85 | ACHE (0.41) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4842140 | 0.83 | CHEK2 (0.53) | ACHEHDAC6ADORA2ACHEK2 | |
| SCHEMBL4842957 | 0.82 | JAK1 (0.40) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2973958 | 0.82 | ACHE (0.60) | ACHEHDAC6ADORA2A | |
| SCHEMBL4844677 | 0.82 | KDM4E (0.47) | CHEK2 | |
| SCHEMBL4841493 | 0.82 | NPC1 (0.50) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
| EP-1539759-A1 | USE OF AND SOME NOVEL IMIDAZOPYRIDINES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016611-A1 | USE OF AND SOME NOVEL IMIDAZOPYRIDINES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | ACHE 1390/4885HDAC3 919/4885HDAC4 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.