Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837663 | 1.00 | AR (0.56) | ARKCNH2SRD5A2 | |
| SCHEMBL2641718 | 1.00 | AR (0.56) | ARKCNH2SRD5A2 | |
| SCHEMBL14223684 | 0.93 | AR (0.60) | ARKCNH2SRD5A2 | |
| SCHEMBL2640079 | 0.88 | AR (0.56) | ARKCNH2SRD5A2 | |
| SCHEMBL4800871 | 0.88 | AR (0.56) | ARKCNH2SRD5A2 | |
| SCHEMBL4800880 | 0.88 | AR (0.56) | ARKCNH2SRD5A2 | |
| SCHEMBL14184883 | 0.88 | AR (0.59) | ARKCNH2SRD5A2 | |
| SCHEMBL8902588 | 0.87 | AR (0.59) | ARKCNH2SRD5A2 | |
| SCHEMBL8902593 | 0.87 | AR (0.59) | ARKCNH2SRD5A2 | |
| SCHEMBL4797509 | 0.85 | AR (0.61) | ARKCNH2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241107-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME LLC | 2006-10-26 | — | — | US | claimed |
| EP-1622567-B1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20080119503-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME CORP. | 2008-05-22 | — | — | US | disclosed |
| US-7351698-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-20060241107-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME LLC | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241107-A1 | Androgen receptor modulators and methods of use thereof | SHBG, FSHR, AR | AR 3/4885KCNH2 4688/4885SRD5A2 57/4885 |
| US-20080119503-A1 | Androgen receptor modulators and methods of use thereof | SHBG, FSHR, AR | AR 3/4885KCNH2 4688/4885SRD5A2 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.