Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483781 | 0.85 | POLB (0.41) | POLBTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL280995 | 0.84 | SCN9A (0.49) | POLBTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL281017 | 0.83 | SCN9A (0.49) | POLBTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL483780 | 0.78 | POLB (0.39) | POLBTSHRALDH1A1L3MBTL1NPC1 | |
| SCHEMBL280866 | 0.75 | SCN9A (0.48) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL281805 | 0.74 | SCN9A (0.61) | POLBTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL280798 | 0.74 | POLB (0.47) | POLBTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL281247 | 0.73 | PTGDR2 (0.44) | POLBMAPT | |
| SCHEMBL280676 | 0.72 | SCN9A (0.58) | POLBTSHRALDH1A1NPC1RAB9A | |
| SCHEMBL2305385 | 0.72 | SCN9A (0.53) | POLBTSHRALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |