Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280995 | 0.79 | SCN9A (0.49) | POLBALDH1A1TP53TSHR | |
| SCHEMBL483779 | 0.78 | POLB (0.42) | POLBALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL281017 | 0.78 | SCN9A (0.49) | POLBALDH1A1TP53TSHR | |
| SCHEMBL483781 | 0.77 | POLB (0.41) | POLBALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL280866 | 0.69 | SCN9A (0.48) | POLBALDH1A1MAPT | |
| SCHEMBL280798 | 0.69 | POLB (0.47) | POLBALDH1A1L3MBTL1TP53TSHR | |
| SCHEMBL281805 | 0.69 | SCN9A (0.61) | POLBALDH1A1TP53TSHR | |
| SCHEMBL281247 | 0.68 | PTGDR2 (0.44) | POLBMAPT | |
| SCHEMBL19562308 | 0.68 | — | — | |
| SCHEMBL280676 | 0.67 | SCN9A (0.58) | POLBALDH1A1NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |