⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL22579069 | 1.00 | LMNA (0.50) | — | |
| Acetic Acid SCHEMBL11079973 | 0.88 | — | — | |
| Acetic Acid SCHEMBL28975648 | 0.85 | — | — | |
| Acetic Acid SCHEMBL28975646 | 0.85 | CA1 (0.57) | — | |
| Acetone SCHEMBL28486857 | 0.83 | LMNA (0.50) | — | |
| Acetone SCHEMBL7686620 | 0.83 | — | — | |
| Acetone SCHEMBL9008051 | 0.83 | LMNA (0.50) | — | |
| Acetone SCHEMBL29265953 | 0.83 | LMNA (0.50) | — | |
| Acetone SCHEMBL8347999 | 0.83 | — | — | |
| Acetone SCHEMBL29203950 | 0.83 | LMNA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240190815-A1 | CRYSTALLINE SOLIDS OF MEK INHIBITOR N-((R)-2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-(2-FLUORO-4-IODO--PHENYLAMINO)-BENZAMIDE AND USES THEREOF | SPRINGWORKS THERAPEUTICS, INC. | 2024-06-13 | — | — | US | disclosed |
| US-11884610-B2 | Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof | SPRINGWORKS THERAPEUTICS, INC. (US) | 2024-01-30 | — | — | US | disclosed |
| US-20230032403-A1 | CRYSTALLINE SOLIDS OF MEK INHIBITOR N-((R)-2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-(2-FLUORO-4-IODO--PHENYLAMINO)-BENZAMIDE AND USES THEREOF | SpringWorks Therapeutics Inc. (US) | 2023-02-02 | — | — | US | disclosed |
| US-11084780-B1 | Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof | SPRINGWORKS THERAPEUTICS, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-7393871-B2 | Anionic and neutral complexes of ruthenium (II) with nitrogen oxide | SIEGA S.R.L. (IT) | 2008-07-01 | — | — | US | disclosed |
| US-20070129343-A1 | New anionic and neutral complexes of ruthenium (II) with nitrogen oxide | MESTRONI GIOVANNI | 2007-06-07 | — | — | US | disclosed |
| US-7169948-B2 | Anionic and neutral complexes of ruthenium (II) with nitrogen oxide | SIGEA S.R.L. (IT) | 2007-01-30 | — | — | US | disclosed |
| EP-1392707-B1 | NEW ANIONIC AND NEUTRAL COMPLEXES OF RUTHENIUM (II) WITH NITROGEN OXIDE | SIGEA SRL (IT) | 2005-11-09 | — | — | EP | disclosed |
| US-20040106799-A1 | Anionic and neutral complexes of ruthenium (II) with nitrogen oxide | SIGEA S.R.L. (IT) | 2004-06-03 | — | — | US | disclosed |
| EP-1392707-A2 | NEW ANIONIC AND NEUTRAL COMPLEXES OF RUTHENIUM (II) WITH NITROGEN OXIDE | Sigea S.R.L. (IT) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002076998-A2 | NEW ANIONIC AND NEUTRAL COMPLEXES OF RUTHENIUM (II) WITH NITROGEN OXIDE | SIGEA S.R.L. (IT) | 2002-10-03 | — | — | WO | disclosed |
| US-5827857-A | BACTERICIDES AND MICROBIOCIDES; GRAMPOSITIVE BACTERIA, HEMOPHILUS INFLUENZA, ANAEROBIC MICROORGANISMS AND MYCOBACTERIA; LOW TOXICITY | BAYER AKTIENGESELLSCHAFT (DE) | 1998-10-27 | — | — | US | disclosed |
| US-4069200-A | STABILIZERS, ANTIOXIDANTS | CIBA-GEIGY CORPORATION (US) | 1978-01-17 | — | — | US | disclosed |
| US-3962377-A | PHOTOCHEMICAL, OXIDATIVE, AND THERMAL STABILIZERS | CIBA-GEIGY CORPORATION (US) | 1976-06-08 | — | — | US | disclosed |