Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 19/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838396 | 1.00 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL14278937 | 0.90 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL4839457 | 0.86 | — | — | |
| SCHEMBL4837707 | 0.86 | — | — | |
| SCHEMBL4830339 | 0.79 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL14278950 | 0.77 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL3292767 | 0.73 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL3285873 | 0.73 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL4830338 | 0.67 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL4830334 | 0.67 | PRMT5 (0.41) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323449-B2 | Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | MERCK & CO., INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-20060122154-A1 | Thionucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | MERCK SHARP & DOHME CORP. | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122154-A1 | Thionucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | NSUN3, NSUN2, RNASE1 | PRMT5 362/4885WDR77 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.