Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 8/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.52 |
| ▸ | CCR2 | P41597 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839388 | 1.00 | SPHK2 (0.52) | SPHK2SPHK1CCR2ALDH1A1KDM4E | |
| SCHEMBL4848314 | 1.00 | SPHK2 (0.52) | SPHK2SPHK1CCR2ALDH1A1KDM4E | |
| SCHEMBL24108929 | 0.85 | HDAC8 (0.44) | SPHK2SPHK1ALDH1A1KDM4EHDAC8 | |
| SCHEMBL10355476 | 0.85 | SPHK1 (0.53) | SPHK2SPHK1ALDH1A1 | |
| SCHEMBL9131967 | 0.85 | SPHK1 (0.53) | SPHK2SPHK1ALDH1A1 | |
| SCHEMBL9134554 | 0.85 | SPHK1 (0.53) | SPHK2SPHK1ALDH1A1 | |
| SCHEMBL4725155 | 0.85 | SPHK2 (0.51) | SPHK2SPHK1 | |
| SCHEMBL2446144 | 0.85 | SPHK2 (0.51) | SPHK2SPHK1 | |
| SCHEMBL9550064 | 0.85 | SPHK2 (0.51) | SPHK2SPHK1 | |
| SCHEMBL7829715 | 0.84 | SIGMAR1 (0.53) | SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390830-B1 | Remedies or prophylactics for diseases in association with chemokines | TEIJIN LIMITED (JP) | 2008-06-24 | — | — | US | disclosed |
| EP-1179341-B1 | REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES | TEIJIN LTD (JP) | 2005-11-09 | — | — | EP | disclosed |
| EP-1553085-A1 | Cyclic amine derivatives and their use as drugs | TEIJIN LIMITED (JP) | 2005-07-13 | — | — | EP | disclosed |
| EP-1535909-A2 | Cyclic amine derivatives and their use as drugs | TEIJIN LIMITED (JP) | 2005-06-01 | — | — | EP | disclosed |
| CN-1384743-A | Remedies or preventives for diseases in association with chemokines | TEIJIN LTD (JP) | 2002-12-11 | — | — | CN | disclosed |
| US-6451842-B1 | Cyclic amine derivatives and their use as drugs | DUPONT PHARMACEUTICALS COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-6410566-B1 | ATHEROSCLEROSIS; ANTIARTHRITIC AGENTS | TEIJIN LIMITED (JP) | 2002-06-25 | — | — | US | disclosed |
| US-6362177-B1 | INHIBITION OF CHEMOKINE BINDING | TEIJIN LIMITED (JP) | 2002-03-26 | — | — | US | disclosed |
| EP-1179341-A1 | REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES | TEIJIN LIMITED (JP) | 2002-02-13 | — | — | EP | disclosed |
| EP-1030840-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS | TEIJIN LIMITED (JP) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999025686-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS | TEIJIN LIMITED (JP) | 1999-05-27 | — | — | WO | disclosed |
| US-4189495-A | TREATMENT OF NERVOUS AND PSYCHOSOMATIC DISORDERS | SYNTHELABO (FR) | 1980-02-19 | — | — | US | disclosed |
| US-4172143-A | PSYCHOSOMATIC AND PSYCHOLOGICAL DISTURBANCES | SYNTHELABO (FR) | 1979-10-23 | — | — | US | disclosed |
| US-4158060-A | PSYCHOLOGICAL DISORDERS | SYNTHELABO (FR) | 1979-06-12 | — | — | US | disclosed |
| US-4021567-A | FOR PSYCHOSOMATIC AND PSYCHOTIC DISTURBANCES | SYNTHELABO (FR) | 1977-05-03 | — | — | US | disclosed |