Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20660884 | 0.80 | ALDH1A1 (0.56) | TTRNPBWR1ALDH1A1NPC1RAB9A | |
| SCHEMBL17430204 | 0.78 | TTR (0.42) | TTRNPBWR1ALDH1A1NPC1RAB9A | |
| SCHEMBL483983 | 0.78 | MAPT (0.52) | TTRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL17430205 | 0.77 | PDGFRB (0.51) | NPBWR1ALDH1A1NPC1RAB9AMAPT | |
| Ammonia Solution, Strong SCHEMBL27894580 | 0.76 | NPC1 (0.47) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL3207284 | 0.76 | ELANE (0.58) | NPBWR1ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL27431081 | 0.73 | ALDH1A1 (0.52) | TTRNPBWR1ALDH1A1NPC1RAB9A | |
| Iodide SCHEMBL27670064 | 0.72 | ALDH1A1 (0.50) | TTRNPBWR1ALDH1A1NPC1RAB9A | |
| SCHEMBL646725 | 0.72 | TTR (0.53) | TTRALDH1A1MAPTSMN1; SMN2CYP1A2 | |
| Ammonia Solution, Strong SCHEMBL27894573 | 0.72 | MAPT (0.51) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2550255-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2016-04-27 | — | — | EP | disclosed |
| CN-103739605-A | Imaging agents for detecting neurological disorders | LILLY CO ELI | 2014-04-23 | — | — | CN | disclosed |
| CN-102985411-A | Imaging agents for detecting neurological disorders | SIEMENS MEDICAL SOLUTIONS | 2013-03-20 | — | — | CN | disclosed |
| EP-2411057-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | Siemens Medical Solutions USA, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111303-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-30 | — | — | WO | disclosed |