Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 17/20 | 0.86 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344499 | 0.88 | ABCG2 (0.67) | ABCG2TGFBR1MAPK14KDM4EPDE5A | |
| SCHEMBL14344506 | 0.86 | ABCG2 (0.64) | ABCG2 | |
| SCHEMBL14344371 | 0.85 | ABCG2 (0.63) | ABCG2 | |
| SCHEMBL14344376 | 0.85 | ABCG2 (0.73) | ABCG2TGFBR1KDM4E | |
| SCHEMBL14344385 | 0.85 | ABCG2 (0.67) | ABCG2 | |
| SCHEMBL14344473 | 0.84 | ABCG2 (0.62) | ABCG2TGFBR1MAPK14 | |
| SCHEMBL14344471 | 0.82 | ABCG2 (0.62) | ABCG2KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL412953 | 0.82 | TGFBR1 (1.00) | ABCG2TGFBR1MAPK14KDM4EPDE5A | |
| SCHEMBL31061048 | 0.82 | TGFBR1 (1.00) | ABCG2TGFBR1MAPK14KDM4EPDE5A | |
| SCHEMBL14344497 | 0.82 | ABCG2 (0.84) | ABCG2KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345045-B2 | Pyrido-pyrimidine compounds as medicaments | SCIOS, INC. (US) | 2008-03-18 | — | — | US | claimed |
| US-7345045-B2 | Pyrido-pyrimidine compounds as medicaments | SCIOS, INC. (US) | 2008-03-18 | — | — | US | disclosed |