Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CYBB | P04839 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | Q9HBH1 | 1/20 | 0.31 | |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281923 | 0.81 | SCN9A (0.57) | SCN9ACDC25AF2F10PLG | |
| SCHEMBL281609 | 0.69 | SCN9A (0.54) | SCN9ACDC25AF2F10PLG | |
| SCHEMBL281760 | 0.68 | SCN9A (0.53) | SCN9ACDC25AALDH1A1MEN1KMT2A | |
| SCHEMBL4168033 | 0.67 | SCN9A (0.55) | SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL4608322 | 0.66 | SCN9A (0.40) | SCN9ACDC25AF2F10PLG | |
| SCHEMBL281890 | 0.66 | SCN9A (0.55) | SCN9ACDC25AF2F10PLG | |
| SCHEMBL281689 | 0.66 | SCN9A (0.55) | SCN9ACDC25AF2F10PLG | |
| SCHEMBL281769 | 0.65 | SCN9A (0.75) | SCN9ACDC25AALDH1A1MEN1KMT2A | |
| SCHEMBL281914 | 0.64 | SCN9A (0.53) | SCN9ACDC25AALDH1A1MEN1KMT2A | |
| SCHEMBL282036 | 0.64 | SCN9A (0.74) | SCN9ACDC25AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |