Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281770 | 0.84 | SCN9A (0.51) | SCN9ACDC25AHTR7CNR2CNR1 | |
| SCHEMBL281914 | 0.70 | SCN9A (0.53) | SCN9ACDC25ACNR2CNR1MEN1 | |
| SCHEMBL4557349 | 0.69 | SCN9A (0.60) | SCN9ACDC25ACNR2CNR1MEN1 | |
| SCHEMBL281923 | 0.69 | SCN9A (0.57) | SCN9ACDC25AMEN1ALDH1A1KMT2A | |
| SCHEMBL281760 | 0.68 | SCN9A (0.53) | SCN9ACDC25ACNR2CNR1MEN1 | |
| SCHEMBL16684342 | 0.68 | FPR2 (0.35) | HTR7CNR2CNR1MEN1ALDH1A1 | |
| SCHEMBL281689 | 0.68 | SCN9A (0.55) | SCN9ACDC25ACNR2CNR1MEN1 | |
| SCHEMBL281809 | 0.66 | SCN9A (0.55) | SCN9AMEN1ALDH1A1KMT2A | |
| SCHEMBL484063 | 0.66 | SCN9A (0.40) | SCN9ACDC25ACNR2CNR1MEN1 | |
| SCHEMBL281890 | 0.66 | SCN9A (0.55) | SCN9ACDC25ACNR2CNR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | claimed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | claimed |