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SCHEMBL4842356

SCHEMBL4842356

CCNC1(C(N)=O)CN(c2nc(C)nc3c(-c4ccc(CC)cc4)c(-c4ccccc4Cl)nn23)C1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 13/20 0.47
▸ CNR2 P34972 3/20 0.40
▸ MAPT P10636 1/20 0.33
▸ GPBAR1 Q8TDU6 1/20 0.33
▸ DCTPP1 Q9H773 1/20 0.32
▸ CDC7 O00311 1/20 0.32
▸ DBF4 Q9UBU7 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ DGAT2 Q96PD7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1315433 0.94 CNR1 (0.54) CNR1CNR2MAPTHPGD
SCHEMBL4841160 0.94 CNR1 (0.48) CNR1CNR2
SCHEMBL4841189 0.91 CNR1 (0.47) CNR1CNR2DGAT2
SCHEMBL4842714 0.91 CNR1 (0.49) CNR1CNR2ALDH1A1
SCHEMBL4837562 0.90 CNR1 (0.45) CNR1CNR2GPBAR1
SCHEMBL4845084 0.88 CNR1 (0.46) CNR1CNR2ALDH1A1HPGD
SCHEMBL4837396 0.86 CNR1 (0.47) CNR1CNR2ALDH1A1DGAT2
SCHEMBL4838215 0.86 CNR1 (0.63) CNR1CNR2MAPT
SCHEMBL4838446 0.86 CNR1 (0.47) CNR1CNR2
SCHEMBL4833674 0.84 CNR1 (0.55) CNR1CNR2DGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7329658-B2 Cannabinoid receptor ligands and uses thereof PFIZER INC (US) 2008-02-12 — — US claimed
EP-1592691-A1 PYRAZOLO[1,5-A][1,3,5]TRIAZINE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS Pfizer Products Inc. (US) 2005-11-09 — — EP claimed
WO-2004069837-A1 PYRAZOLO`1,5-A!`1,3,5!TRIAZINE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS PFIZER PRODUCTS INC. (US) 2004-08-19 — — WO claimed
US-20040157839-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC 2004-08-12 — — US claimed
US-7329658-B2 Cannabinoid receptor ligands and uses thereof PFIZER INC (US) 2008-02-12 — — US disclosed
WO-2006111424-A1 METHODS FOR IDENTIFYING MODULATORS OF CB1 AND CB2 CANNABINOID RECEPTORS AND THEIR USE IN WOUND HEALING LIFE & BRAIN GMBH (DE) 2006-10-26 — — WO disclosed
EP-1592691-A1 PYRAZOLO[1,5-A][1,3,5]TRIAZINE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS Pfizer Products Inc. (US) 2005-11-09 — — EP disclosed
WO-2004069837-A1 PYRAZOLO`1,5-A!`1,3,5!TRIAZINE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS PFIZER PRODUCTS INC. (US) 2004-08-19 — — WO disclosed
US-20040157839-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC 2004-08-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040157839-A1 Cannabinoid receptor ligands and uses thereof CNR1, CNR2, GPR18 CNR1 1/4885CNR2 2/4885MAPT 2827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.