Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2162690 | 0.84 | ADORA2A (0.46) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL31307044 | 0.82 | LMNA (0.48) | ALDH1A1KDM4EGAASMN1; SMN2MEN1 | |
| SCHEMBL31307041 | 0.82 | PTPN1 (0.49) | MAPTALDH1A1KDM4ENPC1GAA | |
| SCHEMBL484156 | 0.79 | RAD51 (0.56) | MAPTALDH1A1KDM4ENPC1GAA | |
| SCHEMBL29892431 | 0.78 | KDM4E (0.49) | MAPTALDH1A1KDM4EGAARAB9A | |
| SCHEMBL22633448 | 0.77 | RAD51 (0.45) | ALDH1A1KDM4ESMN1; SMN2RAD51CSNK1A1 | |
| SCHEMBL2163058 | 0.75 | RAD51 (0.59) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL2162664 | 0.75 | RAD51 (0.40) | RAD51CSNK1A1CLK2LIMK1DYRK1A | |
| SCHEMBL12403623 | 0.75 | ADORA2A (0.41) | RAD51CSNK1A1CLK2LIMK1DYRK1A | |
| SCHEMBL2163292 | 0.75 | RAD51 (0.40) | RAD51CSNK1A1CLK2LIMK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | Siemens Medical Solutions USA, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111303-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-30 | — | — | WO | disclosed |