Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838292 | 0.92 | HDAC3 (0.34) | CHEK2MAPTMMP2MMP9MMP8 | |
| SCHEMBL5260640 | 0.86 | CHEK2 (0.34) | CHEK2MAPTMMP2MMP9MMP8 | |
| SCHEMBL4834997 | 0.84 | HDAC6 (0.36) | CHEK2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4840576 | 0.81 | HDAC6 (0.35) | CHEK2HDAC3HDAC1HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL4843535 | 0.80 | KDM4E (0.38) | MAPTSMN1; SMN2 | |
| SCHEMBL4844169 | 0.79 | CHEK2 (0.37) | CHEK2IKBKETBK1 | |
| SCHEMBL4842378 | 0.78 | CHEK2 (0.38) | CHEK2 | |
| SCHEMBL4841843 | 0.77 | CHEK2 (0.32) | CHEK2TBK1HDAC3HDAC1HDAC2 | |
| SCHEMBL4844120 | 0.76 | CHEK2 (0.36) | CHEK2IKBKEAURKBTBK1 | |
| SCHEMBL4838084 | 0.76 | MAPT (0.43) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | CHEK2 309/4885MAPT 3669/4885NPC1 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.