Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838292 | 0.87 | HDAC3 (0.34) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL4834997 | 0.86 | HDAC6 (0.36) | CHEK2HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL4843544 | 0.86 | CHEK2 (0.34) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL4840576 | 0.81 | HDAC6 (0.35) | CHEK2HDAC6HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL5260635 | 0.80 | — | — | |
| SCHEMBL4841843 | 0.79 | CHEK2 (0.32) | CHEK2HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL4845811 | 0.78 | NPC1 (0.35) | CHEK2HDAC6 | |
| SCHEMBL4844169 | 0.78 | CHEK2 (0.37) | CHEK2 | |
| SCHEMBL4839425 | 0.78 | CHEK2 (0.35) | CHEK2HDAC6 | |
| SCHEMBL4842378 | 0.77 | CHEK2 (0.38) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |