SCHEMBL4843916

SCHEMBL4843916

COC(=O)[C@H]1CN(Cc2ccccc2)C[C@@H]1c1ccc(C)cc1

nearest known ligand 0.67

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.56
SLC6A4 P31645 3/20 0.49
SLC6A2 P23975 2/20 0.49
SLC6A3 Q01959 2/20 0.49
F10 P00742 3/20 0.47
PRSS1 P07477 2/20 0.47
MC4R P32245 1/20 0.47
S1PR1 P21453 1/20 0.46
S1PR5 Q9H228 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9925992 1.00 RORC (0.56) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL4843925 1.00 RORC (0.56) RORCSLC6A4SLC6A2SLC6A3F10
Trifluoroacetic Acid SCHEMBL4845874 0.93 F10 (0.53) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL7888069 0.92 RORC (0.57) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL14498495 0.92 RORC (0.57) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL4661703 0.92 RORC (0.57) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL4661705 0.92 RORC (0.57) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL5110560 0.92 RORC (0.57) RORCSLC6A4SLC6A2SLC6A3F10
SCHEMBL23951589 0.90 RORC (0.56) RORCSLC6A4SLC6A2SLC6A3
SCHEMBL2778339 0.90 RORC (0.56) RORCSLC6A4SLC6A2SLC6A3MC4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230062712-A1 ANTI-ASGR1 ANTIBODY CONJUGATES AND USES THEREOF SILVERBACK THERAPEUTICS, INC. 2023-03-02 US disclosed
US-20200113912-A1 Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates SILVERBACK THERAPEUTICS, INC. (US) 2020-04-16 US disclosed
US-10428045-B2 Benzazepine compounds, conjugates, and uses thereof SILVERBACK THERAPEUTICS, INC. (US) 2019-10-01 US disclosed
US-7468369-B2 Sulfonyl pyrrolidines, method for producing the same and their use as drugs SANOFI-AVENTIS (FR) 2008-12-23 US disclosed
US-20080045540-A1 SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2008-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200113912-A1 Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates CD74, CD47, CD69 RORC 526/4885SLC6A4 3551/4885SLC6A2 1721/4885
US-20080045540-A1 SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS SLC5A1, SLC5A2, KCNJ1 RORC 4022/4885SLC6A4 371/4885SLC6A2 482/4885
US-20230062712-A1 ANTI-ASGR1 ANTIBODY CONJUGATES AND USES THEREOF ASGR1, HAVCR2, FCGR2A RORC 362/4885SLC6A4 4714/4885SLC6A2 4464/4885
US-10428045-B2 Benzazepine compounds, conjugates, and uses thereof TLR8, TLR3, TLR5 RORC 365/4885SLC6A4 977/4885SLC6A2 1849/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.