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Arginine

Arginine

SCHEMBL4843979

N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)O)cc1.N=C(N)NCCC[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)Oc2ccc(C[C@H](N)C(=O)OC(=O)[C@@H](N)Cc3ccc(OC(=O)[C@@H](N)Cc4ccc(OC(=O)[C@@H](N)Cc5ccc(O)cc5)cc4)cc3)cc2)cc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 11/20 0.47
▸ NPY1R P25929 6/20 0.47
▸ SLC7A5 Q01650 2/20 0.46
▸ NPY2R P49146 4/20 0.45
▸ NPY5R Q15761 4/20 0.45
▸ PCNA P12004 1/20 0.39
▸ ITGB3 P05106 1/20 0.39
▸ ITGA2B P08514 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1231526 0.92 SLC7A5 (0.47) NPY4RNPY1RSLC7A5NPY2RNPY5R
SCHEMBL1551972 0.91 SLC7A5 (0.47) NPY4RNPY1RSLC7A5NPY2RNPY5R
SCHEMBL5320701 0.89 NPY4R (0.55) NPY4RNPY1RSLC7A5NPY2RNPY5R
Tyrosine SCHEMBL6690066 0.88 SLC7A5 (0.48) NPY4RNPY1RSLC7A5NPY2RNPY5R
Arginine SCHEMBL10610679 0.87 ITGB3 (0.51) NPY4RNPY1RSLC7A5NPY2RNPY5R
Glycine SCHEMBL5579222 0.87 ITGB3 (0.45) NPY4RNPY1RSLC7A5NPY2RNPY5R
Tyrosine SCHEMBL1551967 0.87 SLC7A5 (0.61) NPY4RNPY1RSLC7A5NPY2RNPY5R
Tyrosine SCHEMBL6368324 0.85 NPY4R (0.58) NPY4RNPY1RSLC7A5NPY2RNPY5R
Arginine SCHEMBL11382644 0.85 ITGB3 (0.48) NPY4RNPY1RSLC7A5NPY2RNPY5R
Phenylalanine SCHEMBL11325686 0.84 NPY4R (0.46) NPY4RNPY1RNPY2RNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7435540-B2 PrPSc-selective peptides IDEXX CORPORATION (US) 2008-10-14 — — US disclosed
US-20060183156-A1 Drug screening; prion disease; Creutzfeldt-Jakob disease; for detecting and for purifying PrPSc CAPRION PHARMACEUTICALS, INC 2006-08-17 — — US disclosed
US-20040072236-A1 PrPSc -interacting molecules and uses thereof IDEXX LABORATORIES, INC. 2004-04-15 — — US disclosed