Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845770 | 1.00 | KDM4E (0.41) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4854007 | 0.93 | PPARG (0.47) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4853994 | 0.93 | PPARG (0.47) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4845621 | 0.84 | PPARG (0.48) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4845632 | 0.84 | PPARG (0.48) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4851132 | 0.84 | PPARG (0.47) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4851145 | 0.84 | PPARG (0.47) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4848460 | 0.83 | PPARG (0.51) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4851592 | 0.83 | PPARG (0.48) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 | |
| SCHEMBL4851599 | 0.83 | PPARG (0.48) | KDM4ESMN1; SMN2HSD17B10TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368578-B2 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20060135578-A1 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135578-A1 | Five-membered heterocyclic compounds | GPR119, OR10J3, CYP11B1 | KDM4E 719/4885SMN1; SMN2 4339/4885HSD17B10 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.