Sugi Predict

Sugi Predict / Compounds / SCHEMBL4845817

SCHEMBL4845817

SCHEMBL4845817

COc1cc(Nc2cccc(Cl)c2)cc2c1N(C)C(=O)OC2(C)c1ccc(Cl)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 11/20 0.58
▸ GSK3B P49841 4/20 0.40
▸ GSK3A P49840 2/20 0.40
▸ STK10 O94804 2/20 0.40
▸ SLK Q9H2G2 2/20 0.40
▸ CLK2 P49760 1/20 0.40
▸ STK33 Q9BYT3 1/20 0.40
▸ CLK4 Q9HAZ1 1/20 0.40
▸ TLK1 Q9UKI8 1/20 0.40
▸ BACE2 Q9Y5Z0 1/20 0.36
▸ MEN1 O00255 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ GAA P10253 1/20 0.35
▸ PDGFRB P09619 1/20 0.35
▸ PDGFRA P16234 1/20 0.35
▸ TNF P01375 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ GMNN O75496 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4846579 0.87 PGR (0.61) PGRGSK3BMEN1MAPTKMT2A
SCHEMBL4848853 0.83 PGR (0.82) PGRMEN1MAPTKMT2AKDM4E
SCHEMBL4848959 0.79 PGR (0.52) PGRBACE2EGFR
SCHEMBL4848686 0.75 PGR (0.68) PGR
SCHEMBL4850869 0.74 PGR (1.00) PGRGSK3BMEN1MAPTKMT2A
SCHEMBL4847868 0.71 PGR (0.69) PGR
SCHEMBL4847803 0.70 PGR (1.00) PGRGSK3B
SCHEMBL4843899 0.70 PGR (0.74) PGR
SCHEMBL4840107 0.65 PGR (1.00) PGR
SCHEMBL4851018 0.64 PGR (0.66) PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7247625-B2 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-07-24 — — US claimed
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH 2005-04-21 — — US claimed
US-7354915-B2 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2008-04-08 — — US disclosed
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-09-27 — — US disclosed
US-7247625-B2 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-07-24 — — US disclosed
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH 2005-04-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 PGR 1/4885GSK3B 4582/4885GSK3A 4673/4885
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 PGR 1/4885GSK3B 4582/4885GSK3A 4673/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.