Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.63 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | THRA | P10827 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 7/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623073 | 0.88 | KMT2A (0.69) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL5974513 | 0.87 | MAOB (0.68) | ALDH1A1MAOBMAOAKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8702528 | 0.86 | KMT2A (0.68) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL3652803 | 0.86 | ESR1 (0.61) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL4638666 | 0.85 | ESR1 (0.67) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL8126769 | 0.85 | ESR1 (0.60) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL14511273 | 0.83 | MAPT (0.53) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL7632070 | 0.82 | ESR1 (0.57) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL4315663 | 0.82 | MAOB (0.62) | ALDH1A1MAOBMAOAKMT2ASMN1; SMN2 | |
| SCHEMBL1436064 | 0.82 | KMT2A (0.76) | MAOBMAOAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |
| EP-1515940-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003097574-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |