Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846612 | 0.82 | ESR1 (0.63) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL6623073 | 0.82 | KMT2A (0.69) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL7632127 | 0.82 | KDM4E (0.52) | ESR1KDM4EALDH1A1THRATHRB | |
| SCHEMBL3652803 | 0.81 | ESR1 (0.61) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8702528 | 0.81 | KMT2A (0.68) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL314013 | 0.81 | KMT2A (0.56) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL8126769 | 0.80 | ESR1 (0.60) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL4638666 | 0.80 | ESR1 (0.67) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL17420486 | 0.77 | KDM4E (0.58) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL11808372 | 0.77 | ESR1 (0.65) | ESR1CHRNB2CHRNA4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350892-B1 | ENZYME INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-26 | — | — | US | disclosed |
| EP-1140791-A2 | SELECTIVE CPLA 2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140791-A4 | SELECTIVE CPLA 2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6255496-B1 | CYTOSOLIC PHOSPHATIDE 2-ACYLHYDROLASE ENZYME INHIBITORS; CONTROLLING INFLAMMATORY DISEASES | BRISTOL-MYERS SQUIBB COMPANY | 2001-07-03 | — | — | US | disclosed |
| WO-1999015129-A2 | SELECTIVE cPLA2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-01 | — | — | WO | disclosed |