Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.61 |
| ▸ | ACHE | P22303 | 6/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849641 | 0.88 | KDM4E (0.56) | BCHEACHEMAPTLMNAMAOB | |
| SCHEMBL4846156 | 0.84 | KDM4E (0.46) | BCHEACHECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29181781 | 0.84 | DPP4 (0.52) | MAPTLMNADPP4HPGDMAOB | |
| SCHEMBL3687525 | 0.81 | MAPT (0.50) | CYP1A2CYP2C19MAPTLMNAHPGD | |
| SCHEMBL1225611 | 0.80 | MAOB (0.71) | CYP1A2CYP3A4CYP2C19MAPTLMNA | |
| SCHEMBL1225612 | 0.80 | MAOB (0.71) | CYP1A2CYP3A4CYP2C19MAPTLMNA | |
| SCHEMBL4846128 | 0.80 | PTPN5 (0.54) | BCHEACHEMAPTLMNAHPGD | |
| SCHEMBL4852869 | 0.80 | KDM4E (0.46) | BCHEACHECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4846138 | 0.80 | KDM4E (0.46) | BCHEACHECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5915668 | 0.80 | MAPT (0.53) | CYP1A2CYP2C19MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |