Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688563 | 0.87 | MAPT (0.47) | MAPTALDH1A1NPC1POLBRAB9A | |
| SCHEMBL3688559 | 0.87 | MAPT (0.47) | MAPTALDH1A1NPC1POLBRAB9A | |
| SCHEMBL3686656 | 0.87 | ALDH1A1 (0.52) | MAPTALDH1A1NPC1POLBRAB9A | |
| SCHEMBL3688379 | 0.83 | MAOB (0.59) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL3684551 | 0.83 | MAOB (0.59) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL3684549 | 0.83 | MAOB (0.59) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5915668 | 0.81 | MAPT (0.53) | MAPTALDH1A1NPC1POLBRAB9A | |
| SCHEMBL4846787 | 0.81 | BCHE (0.61) | MAPTALDH1A1NPC1POLBRAB9A | |
| SCHEMBL3681611 | 0.81 | MAPT (0.51) | MAPTALDH1A1NPC1POLBRAB9A | |
| SCHEMBL1225557 | 0.80 | LMNA (0.65) | MAPTALDH1A1NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |