Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 15/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 14/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851874 | 0.90 | FFAR1 (0.41) | NPC1RAB9ASMN1; SMN2PPARGLMNA | |
| SCHEMBL4848659 | 0.88 | PPARG (0.39) | PPARGPPARA | |
| SCHEMBL4845585 | 0.88 | PPARG (0.38) | RAB9ASMN1; SMN2PPARGPPARAALDH1A1 | |
| SCHEMBL4850429 | 0.88 | PPARG (0.45) | NPC1RAB9ASMN1; SMN2PPARGLMNA | |
| SCHEMBL5374488 | 0.87 | FFAR1 (0.39) | NPC1RAB9ASMN1; SMN2PPARGMAPT | |
| SCHEMBL4852692 | 0.87 | PPARG (0.41) | NPC1RAB9ASMN1; SMN2PPARGLMNA | |
| SCHEMBL4850712 | 0.87 | KDR (0.38) | PPARGPPARAADORA2ADRD2HTR2A | |
| SCHEMBL4848574 | 0.87 | KDR (0.45) | NPC1RAB9ASMN1; SMN2PPARGLMNA | |
| SCHEMBL4848139 | 0.86 | PPARG (0.41) | NPC1RAB9ASMN1; SMN2PPARGLMNA | |
| SCHEMBL4846867 | 0.86 | PPARG (0.47) | NPC1RAB9ASMN1; SMN2PPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368578-B2 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20060135578-A1 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1541564-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135578-A1 | Five-membered heterocyclic compounds | GPR119, OR10J3, CYP11B1 | NPC1 822/4885RAB9A 1036/4885SMN1; SMN2 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.