Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.55 |
| ▸ | MAP3K9 | P80192 | 4/20 | 0.55 |
| ▸ | PRKCA | P17252 | 3/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | PRKCB | P05771 | 1/20 | 0.55 |
| ▸ | GLI1 | P08151 | 1/20 | 0.55 |
| ▸ | GLI2 | P10070 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | PRKACG | P22612 | 1/20 | 0.55 |
| ▸ | PRKACB | P22694 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | PRKCH | P24723 | 1/20 | 0.55 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286 | 0.82 | KDM4E (0.58) | MAP3K11MAP3K9PRKCAPRKCQPRKCD | |
| SCHEMBL619090 | 0.80 | KDR (0.60) | MAP3K11MAP3K9PRKCAPRKCQPRKCD | |
| SCHEMBL34467602 | 0.77 | PRKD3 (0.44) | MAP3K11MAP3K9PRKCAPRKCQPRKCD | |
| SCHEMBL5830601 | 0.76 | HTT (0.50) | MAP3K11MAP3K9PRKCAPRKCQPRKCD | |
| SCHEMBL13025156 | 0.75 | MAP3K11 (0.60) | MAP3K11MAP3K9PRKCAPRKCQPRKCD | |
| SCHEMBL4287798 | 0.72 | KDM4E (0.50) | CHEK1PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL30451928 | 0.72 | KDM4E (0.50) | CHEK1PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL30897563 | 0.72 | MEN1 (0.69) | MAP3K11MAP3K9PRKCAPRKCQPRKCD | |
| SCHEMBL6867398 | 0.71 | CDK4 (0.49) | PRKCAPRKCQPRKCDPRKD3PRKCG | |
| Staurosporinone SCHEMBL29374983 | 0.71 | MAP3K11 (1.00) | MAP3K11MAP3K9PRKCAPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | claimed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | claimed |
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |